TY - JOUR A2 - Mageed, Rizgar AU - Jiang, Hui AU - Liu, Jian AU - Wang, Ting AU - Gao, Jia-rong AU - Sun, Yue AU - Huang, Chuan-bing AU -孟，Mei AU - Qin，Xiu-juan PY - 2016 DA - 2016/02/18 TI -辛丰镇胶囊在Adjuvant-Induced关节炎的机制通过尿代谢组学分析概要SP - 5690935六世- 2016 AB -我们旨在探索新峰胶囊(XFC)的潜在影响在Adjuvant-Induced关节炎(AA)大鼠尿液代谢分析使用气相色谱飞行时间mass spectrometry (GC-TOF/MS). GC-TOF/MS technology was combined with multivariate statistical approaches, such as principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal projections to latent structures discriminant analysis (OPLS-DA). These methods were used to distinguish the healthy group, untreated group, and XFC treated group and elucidate potential biomarkers. Nine potential biomarkers such as hippuric acid, adenine, and L-dopa were identified as potential biomarkers, indicating that purine metabolism, fat metabolism, amino acid metabolism, and energy metabolism were disturbed in AA rats. This study demonstrated that XFC is efficacious for RA and explained its potential metabolomics mechanism. SN - 2090-0422 UR - https://doi.org/10.1155/2016/5690935 DO - 10.1155/2016/5690935 JF - Autoimmune Diseases PB - Hindawi Publishing Corporation KW - ER -