TY - JOUR A2 - Cervera, Ricard AU - Schramm, Amelie M. AU - Clowse, Megan E. B. PY - 2014 DA - 2014/03/20 TI - Aspirin for Prevention of Preeclampsia in Lupus Pregnancy SP - 920467 VL - 2014 AB - Preeclampsia, the onset of hypertension and proteinuria during pregnancy, is a common medical disorder with high maternal and fetal mortality and morbidity. The underlying pathology remains poorly understood and includes inflammation, endothelial dysfunction, and an unbalanced thromboxane A₂/前列环素比。对于女性系统性红斑狼疮（SLE），特别是那些已经存在的与肾脏疾病或患有活动性狼疮，发生先兆子痫的风险高达14％，高于其在健康个体中。该机制仍然是未知的和预防先兆子痫在怀孕狼疮的数据是罕见的。调制所述受损血栓烷₂由低剂量阿司匹林的施用/前列环素比似乎是用于预防先兆子痫的当前最佳的选择。提供先兆子痫，子痫前期在狼疮怀孕，以及预防与阿司匹林先兆子痫的先前试验的发病机制的概况后，我们建议小剂量阿司匹林给药开始之前，妊娠16周的所有狼疮病人。例SLE患者抗磷脂综合征在怀孕期间接受肝素和低剂量的阿司匹林治疗。SN - 2090-0422 UR - https://doi.org/10.1155/2014/920467 DO - 10.1155 /九十二万○四百六十七分之二千○一十四JF - 自身免疫性疾病PB - Hindawi出版公司公司KW - ER -