TY - JOUR A2 - Okamoto, Hiroshi AU - Lun Hon, Kam AU - Leung, Alexander K. C. PY - 2012 DA - 2012/09/02 TI - Neonatal Lupus Erythematosus SP - 301274 VL - 2012 AB - Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with this condition. Neonates with NLE should be managed at a tertiary care center. Multidisciplinary team involvement may also be indicated. In mothers with anti-Ro/SSA and/or anti-La/SSB antibodies and infants with congenital heart block, the risk of recurrence in subsequent offspring is 17–25%. Therefore, careful monitoring of subsequent pregnancies with serial ultrasonography and echocardiography is essential. SN - 2090-0422 UR - https://doi.org/10.1155/2012/301274 DO - 10.1155/2012/301274 JF - Autoimmune Diseases PB - Hindawi Publishing Corporation KW - ER -