TY - JOUR A2 - Amantini, Consuelo AU - Hassan, Snur M. A. AU - Hassan, Ali Hussein PY - 2019 DA - 2019/03/06 TI - Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice SP - 5134156 VL - 2019 AB - 目的。该研究旨在研究小鼠葡萄球钠硫酸钠（DSS-）在小鼠（6-Tg），免疫抑制剂（6-Tg）上对小鼠葡萄球钠硫酸钠（DSS-）诱导的溃疡性结肠炎（UC）的影响。用于治疗溃疡性结肠炎的化疗药物。 材料与方法。将三十六个成人，雄性和雌性BALB / C小鼠随机分为六组：第1组（控制负数）未暴露于DSS并未接受任何治疗，第2组（对照阳性）暴露于DSS但没有收到任何treatment, group 3 exposed to DSS and treated by 0.1 mg/kg of 6-thioguanine, and groups 4, 5, and 6 exposed to DSS and treated by 10, 20, and 40 mg/kg b.w. Shogaol, respectively. At day 56, the mice were checked for their disease activity index (DAI) and they were sacrificed. The colons of the mice were examined for length measurement, histological index score, and the expression of CD133 and CD34 stem cell markers. 结果。Shogaol表现出比6-Tg在脱肠阴水平和傣族分数，结肠长度测量和组织学指数分数所示由Shogaol处理的小鼠显着降低，特别是20和40mg / kg BW剂量。 结论。该研究的结果表明，与姜衍生的物质脱胶的口腔治疗比治疗DSS诱导的UC的常规免疫抑制化学治疗方法6-Tg更好。SN - 2210-7177 UR - https://doi.org/10.1155/2019/5134156 do - 10.1155 / 2019/5134156 jf - 分析蜂窝病理学pb - hindawi kw - er -