TY -的A2 Amantini Consuelo盟——Nissar Bushra盟——Kadla Showkat a . AU -汗,Nuzhat Shaheen AU -沙阿,Idrees a . AU - Majid Misbah盟——Afshan Falaque ul盟——Ganai巴希尔Ahmad PY - 2018 DA - 2018/08/26 TI - DNA修复XRCC1和XPD基因多态性与胃癌风险:来自印度克什米尔的一项病例对照研究结果SP - 3806514 VL - 2018 AB -编码多态性的几个DNA修复基因已被报道影响DNA修复能力，并与许多人类癌症的遗传易感性有关，包括胃癌。了解这些DNA修复基因多态性不仅可以评估人类暴露于环境致癌物的风险，还可以评估他们对以DNA修复途径为靶点的不同治疗方法的反应。在本研究中，我们选择了两个DNA修复基因，XRCC1 Arg399Gln和XPD Lys751Gln的多态变异，研究其与克什米尔人群胃癌易感性的关系。共有180例确诊胃癌(GC)病例和来自斯利那加Shri Maharaja Hari Singh政府医院的200名医院控制者被纳入该研究。采用聚合酶链反应-限制性片段长度多态性对XRCC1和XPD基因进行分型。我们发现吸烟与GC风险密切相关(OR = 25.65;95%置信区间:5.49—-119.7)。然而，我们没有发现XRCC1 Arg399Gln多态性之间的任何关联(OR = 1.56;95% CI: 0.32-7.82)和XPD Lys751Gln (OR = 0.46; CI: 0.10–2.19) with GC risk in the study population. The combination of genotypes and gender stratification of XRCC1 and XPD genotypic frequency did not change the results. Consumption of large volumes of salt tea was also not associated with gastric cancer risk. Polymorphic variants of XRCC1 Arg399Gln and XPD Lys751Gln are not associated with the risk of gastric cancer in the Kashmiri population. However, replicative studies with larger sample size are needed to substantiate the findings. SN - 2210-7177 UR - https://doi.org/10.1155/2018/3806514 DO - 10.1155/2018/3806514 JF - Analytical Cellular Pathology PB - Hindawi KW - ER -