TY -的A2 Marampon Francesco AU - Malik, Arif盟——Sultana Misbah盟,卡齐麦盟卡齐,马哈茂德侯赛因盟——Parveen Gulshan盟——Waquar Sulayman AU -阿什拉夫,Abdul Basit盟——Rasool Mahmood PY - 2016 DA - 2016/02/22 TI -自然辐射敏化剂和癌症细胞抗辐射性的作用:SP - 6146595 VL - 2016 AB -癌症源于基因突变积累。癌症干细胞被描述为具有分化和自我更新能力的致瘤细胞。癌症干细胞被认为对化疗和放疗等传统疗法有耐药性。放射治疗和化疗会损害癌DNA细胞。由于肿瘤干细胞具有自我更新和再生恶性肿瘤的能力，是目前研究的热点。本文综述了CSCs的抗辐射机制，包括DNA损伤反应和天然放射增敏剂。活性氧在不同的生理过程中起着重要的作用。活性氧清除负责调节活性氧的生成。一名研究人员已经证明microrna调节肿瘤辐射抗性。 Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is given mostly in combination with other chemo/radiotherapies. We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds. SN - 2210-7177 UR - https://doi.org/10.1155/2016/6146595 DO - 10.1155/2016/6146595 JF - Analytical Cellular Pathology PB - Hindawi Publishing Corporation KW - ER -