本研究探讨的活性成分
登革热(DF)是一种由蚊子传播的病毒性疾病,已知的主要威胁生命的健康问题之一,由于没有适当的疫苗或治疗。每年,世界各地发生的3.9亿感染的估计[
在矢量控制所采用的最突出的方法是基于使用含有DEET化学杀虫剂的(
该
获得的数据是使用比较
该研究方案经森美兰高教在线三宝垄,印度尼西亚的卫生研究伦理委员会。
优化用1%的Java香茅油用于空气清新剂凝胶式的过程中,使用各种浓度的相关成分的进行,如表
空气清新剂凝胶的几个公式,用1%的Java香茅油。
| 零件 | 配方比例(%) | |||||
|---|---|---|---|---|---|---|
| 一世 | II | III | IV | V | VI | |
| 角叉菜胶 | 3 | 2.5 | 1.5 | 2.5 | 2 | 1.5 |
| 胶 | 0.5 | 1 | 0.5 | 0.5 | 0.5 | 0.5 |
| 苯甲酸钠 | 0.3 | 0.3 | 0.3 | 1 | 1 | 1 |
| 乙二醇 | 1 | 1 | 1 | 1.5 | 2 | 2 |
| 聚山梨酯20 | 0.2 | 0.2 | 0.5 | 0.5 | 0.5 | 1 |
| 生理盐水 | 1 | 1 | 1 | 1 | 1 | 1 |
| Aquadest | 94 | 95 | 96 | 93 | 93 | 92 |
将蒸馏水加入到角叉菜胶,苯甲酸钠,和NaCl,然后将其搅拌,接着在75℃,然后将其降低到65℃的温度下加热混合物。此外,胶基糖,乙二醇,和聚山梨醇酯20被合并,并搅拌直至溶解;爪哇香茅油的1%从热移除之后加入到混合物中。该制剂搅拌以达到均匀并随后在模具中插入,并使其在室温下静置[
六种制剂空气清新剂凝胶。
空气清新剂凝胶的六种制剂在室温下温育,并在特定时间收集少量(
比重of the gel was evaluated using a pycnometer (Iwaki) at room temperature, and the viscosity was determined with the cone and plate geometry viscometer (Brookfield Viscometer), characterized by a typical run of 1.5 rpm at 25°C, using spindle No. 64. Also, the formulations for pH measurement were prepared by dissolving 1 g of gel in 10 ml distilled water, which was further tested with a calibrated pH meter at 5°C and 35°C.
Syneresis is the expulsion of liquid from a gel, which was evaluated by storing the samples at temperatures 5°C and 35°C for 24, 48, and 72 h. These were subsequently placed on a dish to collect the water released during the storage time, and syneresis rate was calculated by determining and comparing the weight loss through the procedure with the initial value.
目前已经在使用基于植物的驱蚊剂的热潮,由于缺乏对人类的不利影响,因为对合成剂,包括DEET(
的三个主要化合物的驱蚊活性分离自
| 活性成分 | 治疗后分(%驱虫活性,平均值) | |||||
|---|---|---|---|---|---|---|
| 五 | 10 | 15 | 30. | 45 | 60 | |
| 香茅醛 | 84.00 | 82.00 | 80.00 | 77.33 | 74.00 | 71.33 |
| 香茅醇 | 86.67 | 84.67 | 82.67 | 80.67 | 78.67 | 77.34 |
| 香叶醇 | 90.67 | 88.00 | 84.67 | 82.00 | 79.33 | 78.00 |
每个驱避活性通过评价对叮咬的保护周期测量
精油组分倾向于经过上储存和处理化学变化,其接着发生所造成的直接暴露于热,湿度,光,或氧[高挥发性和分解的结果
控制从空气清新剂凝胶制剂香茅醛,香茅醇,香叶醇的释放。
| 式 | 香茅醛 | 香茅醇 | 香叶醇 | |||
|---|---|---|---|---|---|---|
|
|
保质期(天) |
|
保质期(天) |
|
保质期(天) | |
| 一世 | 0.8824 | 1.36 | 0.9323 | 12.77 | 0.9699 | 16.82 |
| II | 0.9993 | 15.06 | 0.4808 | - |
0.4808 | - |
| III | 0.9891 | 22.40 | 0.9695 | 1.62 | 0.3952 | - |
| IV | 0.7500 | - |
0.4696 | - |
0.5057 | - |
| V | 0.3952 | - |
0.9845 | 1.12 | 0.4606 | - |
| VI | 0.3952 | - |
0.9308 | 4.04 | 0.8834 | 11.33 |
来自
对空气清新剂的配方进行了以下理化性质的研究,包括比重、粘度、pH值和协同作用。这些与产品稳定性密切相关,结果见表
空气清新剂凝胶配方的理化性质。
| 式 | 比重 | 粘度(CP) | pH值后温度 | |
|---|---|---|---|---|
| 5℃ | 35℃下 | |||
| 一世 | 0.0016 | 34369 | 5.08 | 5.47 |
| II | 0.0052 | 47125 | 5.08 | 5.50 |
| III | 0.0044 | 37419 | 5.91 | 6.43 |
| IV | 0.0051 | 97930 | 7.35 | 6.35 |
| V | 0.0135 | 54425 | 5.23 | 5.55 |
| VI | 0.0063 | 35929 | 6.00 | 6.69 |
Syneresis rate of air freshener gel formulation during storage time (24-72 h).
| 式 | %贮藏后的脱水率 | |||||
|---|---|---|---|---|---|---|
| 5℃ | 35℃下 | |||||
| 24 h | 48 h | 72 h | 24 h | 48 h | 72 h | |
| 一世 | 29.88 | 53.81 | 71.29 | 26.31 | 50.69 | 77.11 |
| II | 25.10 | 39.75 | 57.73 | 27.03 | 50.89 | 69.32 |
| III | 29.12 | 44.60 | 55.64 | 30.66 | 52.05 | 71.29 |
| IV | 42.99 | 65.50 | 75.34 | 28.06 | 46.80 | 69.66 |
| V | 34.44 | 57.64 | 69.93 | 33.01 | 50.50 | 69.15 |
| VI | 5.03 | 10.15 | 16.70 | 26.14 | 43.70 | 62.73 |
角叉菜胶典型地形成高粘度的水溶液,与式I,II,和包含分别为3%,2.5%和2.5%,最高浓度IV。ŤHis has, therefore, been associated with the gel viscosity, as the highest value obtained at a speed of 1.5 rpm (spindles 64) ensued in formula IV, at an average of 97930 cP. Moreover, the air freshener gel was formulated with a combination of carrageenan, NaCl as the salt component, and gum as a dispersing, emulsifying, and suspending agent. In addition, the gum possesses a high viscosity at lower temperatures, as well as pseudoplasticity, and nonsensitivity to temperature, pH, and electrolyte concentration [
协同作用被认为是一种不稳定现象,也被描述为“凝胶的自发收缩,伴随着液体从孔隙中排出”[
角叉菜胶包含20-35%的硫酸,从而影响它的粘度,稳定性,和脱水收缩性,以及附属的这种效果的高浓度和低pH的结果,通过水排出的量所指示的。基于香茅油成分的释放和保质期,配方我归结为最准,虽然公式需要关于稳定在高温下进一步优化。
该驱蚊数据,控释数据,并用于支持该研究的结果所有的物理化学的调查数据请直接从相应的作者。
作者声明,他们没有利益冲突。
这项研究是由资金补助下应用研究发展计划(DIPA 042.01.2.400899/2019)通过研究局和公共服务,科研部,技术和高等教育的印度尼西亚共和国的支持。