57岁的女性与历史在口服皮质类固醇和甲氨蝶呤治疗类风湿性关节炎住院评估疼痛的肿胀的左手(图
1)。她被她的猫咬入学前两天。后咬她的症状包括发烧、恶心、呕吐、严重腹泻。入学那天她出现明显肿胀和变色的背的左手。她深刻的降血压药和缺氧。检查显示老年女性的精神状态改变,昏昏欲睡的双边上肢畸形风湿性关节炎,背的左手肿胀和瘀斑。桡动脉脉搏微弱。APACHE评分和沙发分数25 - 8,分别。实验室调查显示白细胞增多,乳酸酸中毒、急性肾功能衰竭。左手的x射线显示弥漫性软组织肿胀左手以及后遗症先进慢性风湿性关节炎的左手。 Ultrasound of the left hand showed diffuse soft tissue swelling and lymphedema within the dorsum of the hand. Additionally there was dissecting fluid collection in the dorsal soft tissues of the hand measuring 4 cm transverse and 0.7 cm in thickness. The fluid collection appears to dissect over the second, third, and fourth metacarpals. The fluid collection lies approximately 5 mm below the skin surface.
坏死性软组织感染临床特征的暴发性组织破坏,系统性毒性的迹象,和高死亡率。条件与坏死性感染包括糖尿病、吸毒、肥胖、免疫抑制,近期手术,创伤伤口。众所周知,A组链球菌引起皮肤和软组织感染如表面脓疱病、丹毒、坏死性筋膜炎、肌坏死和中毒性休克综合症。条件已经逐渐出现,但随后的过程可能迅速蔓延严重的系统性影响,病死率高。皮肤破裂和垂饰和弗兰克皮肤坏疽可能在几天内观察到。感染可以在几个小时进展涉及相邻肌肉群和软组织导致坏死性肌炎。诊断通常是在手术证实勘探和组织培养的结果。影像学研究可以用于帮助确定肌肉组织是否涉及但不应该延迟手术治疗有捻发音时检查。万古霉素、克林霉素、庆大霉素、灭滴灵的初始选择抗生素。抗生素治疗应调整革兰氏染色剂,文化,和灵敏度结果时可用。 Data evaluating the role of Intravenous Immunoglobulin in the management of necrotizing fasciitis are limited and it is not recommended. Even after early surgical intervention mortality rates of 30–40% are reported with group A streptococci-associated necrotizing fasciitis once the patient has developed septic shock.